Stereospecific effects of d- and l-pentazocine on contractions of the mouse vas deferens |
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| Authors: | K Kinouchi K Fukumitsu J Takezawa S Maeda H Enomoto J Kakuhari I Yoshiya R Inoki |
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| Affiliation: | 1. Department of Anesthesiology and Intensive Care Unit, Osaka University Medical School, Fukushima-ku, Osaka 553, Japan;1. Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil;2. Department of Social and Applied Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;3. GENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, Universidad de Zaragoza, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain;4. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Spain;5. Department of Nutrition and Dietetics, School of Health Science & Education, Harokopio University, Athens, Greece;6. Department of Physiology, School of Medicine, University of Granada, Granada, Spain;7. Department of Physical Education, School of Education, University of Cadiz, Puerto Real, Spain;8. Department of Social Nutrition, State University of Rio de Janeiro, Rio de Janeiro, Brazil;9. Department of Public Health, Ghent University, Ghent, Belgium;10. Council for Agricultural Research and Economics (CREA) - Research Center for Food and Nutrition, Rome, Italy;11. ImFINE Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Física y del Deporte (INEF), Universidad Politécnica de Madrid, Madrid, Spain;12. 8 Univ. Lille2, CHU Lille, LIRIC-UMR995, Lille, France;13. Preventive Medicine and Nutrition Clinic, University of Crete, Heraklion, Greece;14. Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain;15. Department of Pediatrics, Private Medical University, Salzburg, Austria;p. Department of Pediatrics, Medical Faculty, University of Pécs, Pecs, Hungary;1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA;2. Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, USA;1. Capital Medical University, Beijing, China;2. Beijing Key Laboratory of Pediatric Otolaryngology, Head & Neck Surgery, Beijing Pediatric Research Institute, Beijing Children''s Hospital, Capital Medical University, National Center for Children''s Health, Beijing, China;3. Center for Clinical Epidemiology & Evidence-based Medicine, Beijing Children''s Hospital, Capital Medical University, National Center for Children''s Health, Beijing, China;4. Otolaryngology, Head and Neck Surgery Department, Beijing Children''s Hospital, Capital Medical University, National Center for Children''s Health, Beijing, China;5. Respiratory Department, Beijing Children''s Hospital, Capital Medical University, National Center for Children''s Health, Beijing, China;6. Department of Child Health, University of Missouri School of Medicine, Columbia, MO, USA;1. Transplant Immunology Laboratory, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;2. Nephrology and Transplantation Service, Hôpital Saint-Louis, Paris, France;3. Department of Medicine, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;4. Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, USA;1. Department of Anthropology, University of Delhi, Delhi, 110007, India;2. National Institute of Epidemiology, Social and Behavioural Sciences, Chennai, 600012, Tamil Nadu, India |
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| Abstract: | The effects of the d- and l-isomers of pentazocine were compared to that of racemic pentazocine on contractions of the mouse isolated vas deferens. L-pentazocine inhibited electrically evoked contractions of the mouse vas deferens (MVD) in a dose-dependent manner (ID50 0.37 +/- 0.04 microM). In contrast, d-pentazocine augmented field stimulated contractions dose-dependently; per cent increases in contractions at 10 and 30 microM were 57.8 +/- 18.0 and 98.0 +/- 15.1%, respectively. Racemic pentazocine produced an intermediate effect between the two isomers. The effect of 1-pentazocine was antagonized by naloxone, whereas that of d-pentazocine was not. L-pentazocine did not effect the response of the MVD to exogenous norepinephrine at any concentration tested, while d-pentazocine depressed the response of the MVD to exogenous norepinephrine at one dose (0.3 microM). These findings demonstrate that d- and l-pentazocine produce opposite effects on the MVD. The effects of l-pentazocine are opioid mediated, while those of d-pentazocine are not. In the racemic mixture the opposing effects of the two isomers modulate each other, resulting in a diminished effect. |
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