Cariniferosides A–F and other steroidal biglycosides from the starfish Asteropsis carinifera |
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Authors: | Timofey V. Malyarenko Alla A. Kicha Natalia V. Ivanchina Anatoly I. Kalinovsky Pavel S. Dmitrenok Svetlana P. Ermakova Valentin A. Stonik |
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Affiliation: | Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia |
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Abstract: | Six new steroidal biglycosides, cariniferosides A–F (1–6), were isolated along with six previously known glycosides, 7–12, from the alcoholic extract of the starfish Asteropsis carinifera. The structures of 1–6 were determined by extensive NMR and ESIMS techniques. The isolated compounds did not show any apparent cytotoxicity in cancer cell lines HCT-116, RPMI-7951, and T-47D, but sulfated compounds 6, 11, and 12 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in a soft agar clonogenic assay. |
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Keywords: | Steroids Glycosides Starfish Asteropsis carinifera Cytotoxicity Clonogenic assay |
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