Monocytes are essential for inhibition of synovial T-cell glucocorticoid-mediated apoptosis in rheumatoid arthritis |
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| Authors: | Dimitrios Makrygiannakis Shankar Revu Petra Neregård Erik af Klint Omri Snir Cecilia Grundtman Anca Irinel Catrina |
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| Institution: | (1) Department of Rheumatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, S-17176, Sweden |
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| Abstract: | Introduction Rheumatoid arthritis (RA) is characterized by synovial inflammation with local accumulation of mononuclear cells such as macrophages
and lymphocytes. We previously demonstrated that intra-articular glucocorticoids decrease the synovial tissue (ST) T-cell
population and therefore aimed to investigate whether this is mediated through modulation of apoptosis. |
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