Expression of recombinant <Emphasis Type="Italic">Clostridium difficile</Emphasis> toxin A and B in <Emphasis Type="Italic">Bacillus megaterium</Emphasis>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Expression of recombinant <Emphasis Type="Italic">Clostridium difficile</Emphasis> toxin A and B in <Emphasis Type="Italic">Bacillus megaterium</Emphasis>

Authors:	Guilin Yang Boping Zhou Jufang Wang Xiangyun He Xingmin Sun Weijia Nie Saul Tzipori Hanping Feng

Institution:	(1) Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, 01536 North Grafton, Massachusetts, USA;(2) Institute of Hepatology, Shenzhen East Lake Hospital, 518020 Shenzhen, PR China;(3) The Department of Biochemical Engineering, School of Bioscience and Biotechnology, South China University of Technology (SCUT), 510006 Guangzhou, PR China

Abstract:	Background Major Clostridium difficile virulence factors are the exotoxins TcdA and TcdB. Due to the large size and poor stability of the proteins, the active recombinant TcdA and TcdB have been difficult to produce.

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