The Hardy-Weinberg principle and its applications in modern population genetics |
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| Authors: | John J Chen |
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| Institution: | 1.Department of Preventive Medicine,State University of New York at Stony Brook,Stony Brook,USA |
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| Abstract: | The discovery of the Hardy-Weinberg principle marked the beginning of the field of population genetics. Over the past hundred
years, it has provided a starting point for many population genetic investigations. In this review, the Hardy-Weinberg principle,
its statistical testing, and several of its applications in various modern population genetic research areas, including allelic
variability and selection in the human leukocyte antigen region, microsatellite genotyping error detection, and accuracy of
haplotype estimation, are discussed. |
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| Keywords: | the Hardy-Weinberg principle statistical testing population genetics human leukocyte antigens microsatellite genotyping haplotype estimation |
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