NCAM Mimetic Peptides: Potential Therapeutic Target for Neurological Disorders |
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| Authors: | Chengyan Chu author-information" >,Yue Gao,Xiaoyan Lan,Aline Thomas,Shen Li |
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| Affiliation: | 1.Department of Neurology,Dalian Municipal Central Hospital Affiliated to Dalian Medical University,Dalian,China;2.Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research,The Johns Hopkins University School of Medicine,Baltimore,USA;3.Department of Neurological Rehabilitation,The Second Hospital of Dalian Medical University,Dalian,China |
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| Abstract: | The neural cell adhesion molecule (NCAM) plays a pivotal role in the development and maintenance of the nervous system via homophilic (NCAM–NCAM) and heterophilic (NCAM-other molecules) interactions. Many synthetic peptides have been engineered to mimic these interactions and induce NCAM-downstream signaling pathways. Such NCAM mimetics have displayed neuritogenic and neuroprotective properties, as well as synaptic modulation in vitro and in vivo. Furthermore, they have been used successfully in preclinical studies to treat neurological disorders including stroke, traumatic brain injury and Alzheimer’s disease. This review focuses on recent progress in the development of NCAM mimetic peptides, in particular, on establishing C3, plannexin, and FGL as therapeutic candidates for neurological disorders. |
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