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Sequence of the dog immunoglobulin alpha and epsilon constant region genes |
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| Authors: | Mayuri Patel Douglas Selinger George E Mark Gerard J Hickey Gregory F Hollis |
| Institution: | (1) Department of Cellular and Molecular Biology, Merck Research Laboratories, R80Y-160, P. O. Box 2000, 07065 Rahway, NJ, USA;(2) Department of Animal Drug Evaluation, Merck Research Laboratories, 07065 Rahway, NJ, USA;(3) Present address: Experimental Station, E 400/5207, DuPont Merck Pharmaceutical Co., P.O. Box 80 400, 19880-0400 Wilmington, DE, USA |
| Abstract: | The immunoglobulin alpha (IGHAC) and epsilon (IGHEC) germline constant region genes were isolated from a dog liver genomic DNA library. Sequence analysis indicates that the dog IGHEC gene is encoded by four exons spread out over 1.7 kilobases (kb). The IGHAC sequence encompasses 1.5 kb and includes all three constant region coding exons. The complete exon/intron sequence of these genes is described.The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession numbers L 36871 (dog IGHAC) and L 36872 (dog IGHEC) |
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