Peptide Fragments and Structural Analogues of Chemokine MCP-1: Synthesis and Effect on the MCP-1-Induced Migration of Mononuclear Cells |
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| Authors: | Sidorova M. V. Molokoedov A. S. Aref'eva T. I. Kukhtina N. B. Krasnikova T. L. Bespalova Zh. D. Bushuev V. N. |
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| Affiliation: | (1) Cardiological Research and Production Association, Ministry of Health of the Russian Federation, ul. Tret'ya Cherepkovskaya 15a, Moscow, 121552, Russia |
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| Abstract: | Fourteen fragments and structural analogues of chemokine MCP-1 were synthesized using the Fmoc-strategy of solid phase peptide synthesis. The effect of synthesized peptides on the MCP-1-stimulated migration of mononuclear cells was examined. Both in vitro stimulants and inhibitors of the monocyte migration were found among the peptides. A possible participation of the C-terminal part of the MCP-1 molecule in the inhibition of the MCP-1-stimulated cell migration was found for the first time. |
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| Keywords: | chemokine MPC-1 monocytes MCP-1-induced migration solid phase peptide synthesis synthetic peptides |
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