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The discovery of adamantyl-derived, inhaled, long acting beta(2)-adrenoreceptor agonists |
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| Authors: | Brown Alan D Bunnage Mark E Glossop Paul A James Kim Jones Rhys Lane Charlotte A L Lewthwaite Russell A Mantell Simon Perros-Huguet Christelle Price David A Trevethick Mike Webster Rob |
| Affiliation: | Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. |
| Abstract: | The design and profile of a series of adamantyl-containing long acting beta(2)-adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using a guinea pig trachea tissue model. A focus was then placed on developing a robust synthetic route to ensure rapid delivery of material for clinical trials. |
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