Phage lytic proteins: biotechnological applications beyond clinical antimicrobials |
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| Authors: | Lorena Rodríguez-Rubio Diana Gutiérrez David M Donovan Beatriz Martínez Ana Rodríguez |
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| Institution: | 1. DairySafe Group, Department of Technology and Biotechnology of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Villaviciosa, Asturias, Spain and;2. Animal Biosciences and Biotechnology Laboratory, BARC, ARS, USDA, Beltsville, MD, USA |
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| Abstract: | Most bacteriophages encode two types of cell wall lytic proteins: endolysins (lysins) and virion-associated peptidoglycan hydrolases. Both enzymes have the ability to degrade the peptidoglycan of Gram-positive bacteria resulting in cell lysis when they are applied externally. Bacteriophage lytic proteins have a demonstrated potential in treating animal models of infectious diseases. There has also been an increase in the study of these lytic proteins for their application in areas such as food safety, pathogen detection/diagnosis, surfaces disinfection, vaccine development and nanotechnology. This review summarizes the more recent developments, outlines the full potential of these proteins to develop new biotechnological tools and discusses the feasibility of these proposals. |
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| Keywords: | Biotechnology disinfection endolysins food safety nanotechnology pathogen detection vaccines virion-associated peptidoglycan hydrolases |
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