The occurrence of lipidic particles in lipid bilayers as seen by 31P NMR and freeze-fracture electron-microscopy |
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| Authors: | B De Kruijff AJ Verkley CJA Van Echteld WJ Gerritsen C Mombers PC Noordam J De Gier |
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| Institution: | Department of Molecular Biology and Department of Biochemistry, State University of Utrecht, Padualaan 8, Utrecht The Netherlands |
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| Abstract: | A new type of lipid organization is observed in mixtures of phosphatidylcholine with cardiolipin (in the presence of Ca2+), monoglucosyldiglyceride and phosphatidylethanolamine (in the presence of cholesterol). This phase is characterised by an isotropic 31P NMR signal and is visualised by freeze-fracturing as particles and pits on the fracture faces of the lipid bilayer. As the most favourable model for this phase we propose the inverted micelle sandwiched in between the two monolayers of the lipid bilayer. |
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| Keywords: | Lipid particles Freeze fracture (Inverted micelle) |
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