| 用重组痘苗病毒感染动物细胞表达的Epstein-Barr病毒膜抗原检查IgA/MA抗体 |
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| 引用本文： | 皮国华,谷淑燕,江民康,叶树清,赵文平,曾毅,H.Wolf.用重组痘苗病毒感染动物细胞表达的Epstein-Barr病毒膜抗原检查IgA/MA抗体[J].病毒学报,1987(4). |
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| 作者姓名： | 皮国华 谷淑燕 江民康 叶树清 赵文平 曾毅 H.Wolf |
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| 作者单位： | 中国预防医学科学院病毒学研究所，中国预防医学科学院病毒学研究所，中国预防医学科学院病毒学研究所，中国预防医学科学院病毒学研究所，中国预防医学科学院病毒学研究所，中国预防医学科学院病毒学研究所，西德Max V Pettenkofer研究所 北京，北京，北京，北京，北京，北京，慕尼黑 |
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| 摘 要： | 用EB病毒膜抗原基因重组的痘苗病毒感染动物细胞,其细胞表面可表达EB病毒膜抗原,以此膜抗原作为诊断抗原检测血清中IgA/MA抗体,明显优于常用的B95-8细胞表面膜抗原,从而为研究人群血清抗体反应与鼻咽癌的关系,为鼻咽癌的诊断和普查开辟了新的途径。
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| 关 键 词： | 鼻咽癌 Epstein-Barr病毒膜抗原 基因工程抗原 痘苗病毒 |
DETECTION OF IgA ANTIBODY TO EPSTEIN-BARR VIRUS MEMBRANE ANTIGEN EXPRESSED BY RECOMBINANT VACCINIA VIRUS |
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| Pi Guohua Gu Shuyan Jiang Minkang Ye Shuqing Zhao Wengping Zeng Yi Hans Wolf Institute of Virology,Chineses Academy of Preventive Medicine,BeijingMax. V. Pettenkofer institute,W. Germany Munich.DETECTION OF IgA ANTIBODY TO EPSTEIN-BARR VIRUS MEMBRANE ANTIGEN EXPRESSED BY RECOMBINANT VACCINIA VIRUS[J].Chinese Journal of Virology,1987(4). |
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| Authors: | Pi Guohua Gu Shuyan Jiang Minkang Ye Shuqing Zhao Wengping Zeng Yi Hans Wolf Institute of Virology Chineses Academy of Preventive Medicine BeijingMax V Pettenkofer institute W Germany Munich |
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| Abstract: | EBV membrane antigen was expressed from infected cells with recombi-nant vaccinia virus. As a diagnostic antigen, the presence of IgA antibody to membrane antigen of EBV was tested in sera from NPC patients, patients with tumors other than NPC and normal individuals. Our data indicate that gentic engineered EBV membrane antigen is specific, more sensitive and simpler than B95-8 cell line for the detection of IgA/MA antibodies in sera from different groups. It is a new advanced technic for NPC early diag nosis and mass survey. |
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| Keywords: | Nasopharyngeal carcinoma Epstein-Barr virus membrane antigen Genetic engineered antigen Vaccinia virus |
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