Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3 |
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| Authors: | Posner Gary H Crawford Kenneth R Yang Hong Woon Kahraman Mehmet Jeon Heung Bae Li Hongbin Lee Jae Kyoo Suh Byung Chul Hatcher Mark A Labonte Tanzina Usera Aimee Dolan Patrick M Kensler Thomas W Peleg Sara Jones Glenville Zhang Anqi Korczak Bozena Saha Uttam Chuang Samuel S |
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| Institution: | Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218-2685, USA. ghp@jhu.edu |
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| Abstract: | The new 24-phenylsulfone 4a, a low-calcemic analog of the natural hormone 1alpha,25-dihydroxyvitamin D(3), is a potent (IC(50) = 28nM) and highly selective inhibitor of the human 24-hydroxylase enzyme CYP24. |
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