Synthesis and mannose receptor-mediated uptake of clustered glycomimetics by human dendritic cells: effect of charge |
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| Authors: | Angyalosi Gerhild Grandjean Cyrille Lamirand Mélanie Auriault Claude Gras-Masse Hélène Melnyk Oleg |
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| Institution: | SEDAC-Therapeutics, Parc Eurasanté, Le Galenis, Bat B, 85 rue Nelson Mandela, 59120 Loos, France. |
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| Abstract: | Effect of charge and shape of multivalent lysine-based cluster glycomimetics on their mannose receptor-mediated uptake by human dendritic cells has been evaluated: The capture is strongly affected by the shape of the ligands. The effect of charge is less pronounced although positive charges on the ligands seem to favor non-specific endocytosis capture. |
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