Synthesis and DNA-recognition and -cleavage properties of multiply charged porphyrin esters |
| |
Authors: | Wu Lin Hu Peng Xiao Ying Zhang Ming Zhang Lixia Weng Xiaocheng Wu Xiaojun Zhou Xiang Cao Xiaoping |
| |
Institution: | College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR of China. |
| |
Abstract: | A series of systematically modified porphyrin esters, compounds 1-6, with multiple, permanent positive charges introduced at the meso-positions via N-methylated 4-, 3-, or 2-pyridyl moieties, were prepared and characterized. Their singlet-oxygen production, CT-DNA-binding properties, and plasmid-DNA photocleavage propensities were determined spectroscopically and by gel electrophoresis, and compared to those of the known, fourfold-charged parent porphyrin 4,4',4',4'-porphyrin-5,10,15,20-tetrayltetrakis(1-methylpyridinium) (TMPyP4). Some interesting structure-activity relationships could be established to rationalize effects affecting DNA binding mode and cleavage ability. |
| |
Keywords: | DNA Porphyrin esters Structure–activity relationships |
本文献已被 PubMed 等数据库收录! |
|