Antiulcerogenic and anti-inflammatory effects of emodin, isolated from Rhamnus triquerta wall |
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| Authors: | R K Goel G Das Gupta S N Ram V B Pandey |
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| Institution: | Department of Pharmacology, Banaras Hindu University, Varanasi, India. |
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| Abstract: | Emodin, an anthraquinone derivative, isolated from the whole plant of R. triquerta, in 15 mg/kg dose (ip) exhibited anti-inflammatory activity against carrageenin-induced pedal inflammation in rats. In the same dosage it also showed antiulcer activity against 4 hr pylorus-ligated, aspirin and immobilization stress-induced gastric ulcers in rats. It decreased acid and pepsin output and augmented mucus secretion in terms of total carbohydrate: protein ratio in the gastric juice of aspirin treated pylorus-ligated rats, indicating that the antiulcerogenic effect of emodin may be due to its effect on gastric secretion. |
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