Monoclonal antibodies to endotoxin in the management of sepsis. |
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Authors: | K C Fang |
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Institution: | Department of Medicine, University of California, School of Medicine, San Francisco. |
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Abstract: | New monoclonal antibodies directed against the lipid A moiety of the endotoxin present in gram-negative bacteria have been developed to improve the clinical outcome in patients with sepsis. Two studies of monoclonal antibodies HA-1A and E5 retrospectively identified specific patient subgroups showing benefit with therapy. I analyze and summarize the new sepsis nomenclature, the structure of endotoxin, the data implicating endotoxin as a causative agent in septic patients'' morbidity and mortality, and specific data from the 2 clinical studies of monoclonal antibody therapy. |
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