Effect of N-terminal deletion of signal peptide on the secretion of human granulocyte-colony stimulating factor in mammalian cells |
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| Authors: | Tetsuro Kuga Yoshinori Komatsu Tamio Mizukami Moriyuki Sato Seiga Itoh |
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| Affiliation: | (1) Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahimachi, 194 Machidashi, Tokyo, Japan;(2) Present address: Technical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd., 1-1 Kyowamachi, 747 Hofushi, Yamaguchi, Japan |
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| Abstract: | Summary The nine N-terminal amino acids of signal peptide differ between human and mouse granulocyte-colony stimulating factors (G-CSF). To study the function of this non-conserved sequence, cDNA lacking the sequence has been constructedinvitro. The deleted signal peptide promoted the secretion of hG-CSF in CHO cells. |
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