Characterization of <Emphasis Type="Italic">Mycobacterium tuberculosis</Emphasis> Central Asian Strain1 using mycobacterial interspersed repetitive unit genotyping期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Characterization of Mycobacterium tuberculosis Central Asian Strain1 using mycobacterial interspersed repetitive unit genotyping

Authors:	Asho Ali Zahra Hasan Mahnaz Tanveer Amna R Siddiqui Solomon Ghebremichael Gunilla Kallenius Rumina Hasan

Affiliation:	(1) Department of Pathology and Microbiology, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan;(2) Department of Community Health Sciences, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan;(3) Department of Bacteriology, Swedish Institute for Infectious Diseases Control, Stockholm, Sweden;(4) Microbiology and Tumor Cell Biology, Karolinska Institute, Nobels Vag 16, Stockholm, Sweden

Abstract:	Background The Central Asian Strain1 (CAS1) genogroup of Mycobacterium tuberculosis (MTB) is the most prevalent in Pakistan, India and Bangladesh. Mycobacterial interspersed repetitive units variable number tandem repeat (MIRU-VNTR) typing is a reliable and reproducible method for differentiation of MTB isolates. However, information of its utility in determining the diversity of CAS1 strain is limited. We performed standard 12 loci based MIRU-VNTR typing on previously spoligotyped CAS1 strains and 'unique' strains in order to evaluate its discriminatory power for these isolates.

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