Leukocyte migration: dismantling inhibition |
| |
Authors: | Brown Eric J |
| |
Affiliation: | Program in Microbial Pathogenesis and Host Defense, University of California-San Francisco, Campus Box 2140, 600 16th Street, San Francisco, CA 94123, USA. ebrown@medicine.ucsf.edu |
| |
Abstract: | A new study demonstrates that the Src-family kinases Fgr and Hck inhibit chemokine signaling in polymorphonuclear leukocytes and dendritic cells by phosphorylation of PIR-B, an inhibitory receptor expressed on leukocytes. In resting cells, PIR-B phosphorylation is constitutive but is decreased transiently by addition of chemokines. In Fgr/Hck-deficient cells, constitutive PIR-B phosphorylation is markedly decreased. These Src-family kinases have a novel role in tonic inhibition of cell activation that must be overcome to allow the phenotypic effects of chemokine signaling through G-protein-coupled receptor ligands. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|