Synthesis and Pharmacological Activity of Betulin Dinicotinate |
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| Authors: | Flekhter O. B. Karachurina L. T. Nigmatullina L. R. Sapozhnikova T. A. Baltina L. A. Zarudii F. S. Galin F. Z. Spirikhin L. V. Tolstikov G. A. Plyasunova O. A. Pokrovskii A. G. |
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| Affiliation: | (1) Ufa Scientific Center, Russian Academy of Sciences, Institute of Organic Chemistry, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054, Russia;(2) Laboratory of Retroviruses, Institute of Molecular Biology, NPO Vector, pos. Kol'tsovo, Novosibirsk oblast, 633159, Russia |
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| Abstract: | The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3O,28O-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. |
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| Keywords: | betulin dinicotinate hepatoprotective immunomodulatory antiulcer anti-HIV activities lupane triterpenoids |
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