"Wet dog shakes" during olfactory bulb kindling |
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| Authors: | M Ben Attia P N'Gouemo M Belaidi M Lerner-Natoli G Rondouin M Baldy-Moulinier |
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| Institution: | Laboratoire de Médecine Expérimentale (CNRS UPR-41, INSERM U.249), Institut de Biologie, Faculté de Médecine, Montpellier. |
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| Abstract: | Kindling phenomenon provides an experimental model of limbic secondarily generalized epilepsy. It can be easily obtained by stimulation of the olfactory bulb (OB) which is strongly connected to limbic structures. The after-discharge induced by subconvulsant electrical stimulations, is followed by a behavioral phenomenon, named Wet Dog Shakes (WDS). In the course of the Rat OB kindling, the development of WDS is biphasic: 1) an ascendant phase during the first three stages, and 2) a descendant phase in the stages 4 and 5, that may give evidence of the installation and the intensification of the kindling process. The significance of this behavior in seizure generalization is discussed. |
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