New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. |
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| Authors: | Silvère Aubriot Edwige Nicolle Mireille Lattier Cécile Morel Wenhong Cao Kiefer W Daniel Sheila Collins Gérard Leclerc Patrice Faure |
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| Affiliation: | Département de Pharmacochimie Moléculaire, UMR-CNRS 5063, UFR de Pharmacie, Université Joseph Fourier, BP 138, F-38243 Meylan cedex, France. |
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| Abstract: | A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the beta(3)-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities. |
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