Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells |
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Authors: | H Matsunaga N Yamashita Y Maruyama I Kojima K Kurokawa |
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Institution: | Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan. |
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Abstract: | We analyzed inward Ca2+ currents in single bovine adrenal glomerulosa cell using whole-cell patch clamp techniques. Two types of voltage-gated Ca2+ channel currents were identified. One was a transient (T) type which decayed within 100 ms, characterized by a low threshold voltage (about -70 mv) similar to that seen in rat adrenal glomerulosa cells (Matsunaga, H. et al. (1987) Pflügers Arch. 408, 351-355.) Another was a long-lasting (L) type which shows a more positive threshold potential. The present results suggest that while T type Ca2+ channels may explain initial calcium influx in response to an elevation in extracellular K+, L type Ca2+ channels may allow sustained calcium influx which is necessary for sustained aldosterone secretion. |
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