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A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors
Authors:Daniele Di Marino  Ilda D'Annessa  Holly Tancredi  Claudia Bagni  Emilio Gallicchio
Institution:1. Department of Chemistry, Brooklyn College of the City University of New York, Brooklyn, New York;2. Department of Biology, University of Rome Tor Vergata, Rome, Italy;3. Department of Computer Science, Brooklyn College of the City University of New York, Brooklyn, New York;4. VIB Center for the Biology of Disease, Leuven, Belgium;5. Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), Leuven, Belgium;6. Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
Abstract:
Keywords:CYFIP1  eIF4E  inhibitor peptides  molecular dynamics simulation  binding energy distribution analysis method  alchemical simulations  conformational search
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