Low platelet monoamine oxidase activity and chronic marijuana use |
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| Authors: | Richard C. Stillman Richard Jed Wyatt Dennis L. Murphy Frederick P. Rauscher |
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| Affiliation: | 1. Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, Intramural Research Program, Saint Elizabeths Hospital Washington, D.C. 20032, USA;2. Intramural Research Program, Division of Research National Institute on Drug Abuse, Rockville, Maryland 20903, USA;3. Clinical Neuropharmacology Branch, National Institute of Mental Health Bethesda, Maryland 20014, USA |
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| Abstract: | Mean platelet monoamine oxidase (MAO) activity in 26 consecutively-studied male marijuana smokers was significantly lower than in a comparable group of non-marijuana smoking males. In addition, the level of current marijuana use reported by the subjects was significantly and inversely correlated with MAO activity. No acute reduction in MAO activity was found in response to smoking a marijuana cigarette containing 15 mg of delta-9-THC. Significant inhibition of MAO activity by THC was detected only at THC concentrations above 10?5M, approximately 100 times the peak plasma concentrations seen following smoking. |
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