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Choline: Selective enhancement of serial learning and encoding of low imagery words in man |
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| Authors: | N Sitaram Herbert Weingartner Eric D Caine J Christian Gillin |
| Institution: | 1. Biological Psychiatry Branch National Institute of Mental Health, Bethesda, Maryland 20014, USA;2. Laboratory of Clinical Science National Institute of Mental Health, Bethesda, Maryland 20014, USA;3. Laboratory of Clinical Psychology National Institute of Mental Health, Bethesda, Maryland 20014, USA;4. Laboratory of Clinical Psychopharmacology, NIMH, St. Elizabeth''s Hospital, Washington, D.C. 20032, USA |
| Abstract: | The effect of a single oral dose of choline chloride (10g) on two kinds of memory measures (serial learning and a selective reminding task) was studied in 10 normal volunteers. Choline decreased significantly the number of trials required to master a serial learning word test. On the selective reminding task only the recall of poorly imageable words (which are ordinarily difficult to remember) was enhanced by choline. Words which were highly imageable (and ordinarily easy to remember) were unaffected. The degree of enhancement with choline correlated inversely with performance of subjects on placebo. Our data indicate that brain acetylcholine may play a facilitatory role in encoding and storage of specific information items in man. |
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