Selective depletion of spinal noradrenaline abolishes post-decapitation convulsions |
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| Authors: | David C.S. Roberts Stephen T. Mason Hans C. Fibiger |
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| Affiliation: | Division of Neurological Sciences Department of Psychiatry University of British Columbia Vancouver, B.C., Canada V6T 1W5 |
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| Abstract: | Previous data have suggested that spinal noradrenaline (NA) might be important in the normal expression of post-decapitation convulsions. This hypothesis was tested by selective depletion of spinal NA through stereotaxic infusions of 6-hydroxydopamine into the medulla in adult rats. This treatment was found to substantially reduce spinal NA and to abolish the post-decapitation convulsions. The results are discussed in terms of the mechanism underlying the involvement of NA in this reflex. |
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