Effect of delta-aminolevulinic acid on frog nerve-muscle function |
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Authors: | M.G. Cutler J.M. Dick M.R. Moore |
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Affiliation: | 1. Department of Biological Sciences, Glasgow College of Technology, UK;2. Department of Materia Medica, University of Glasgow, UK |
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Abstract: | Effects of delta-aminolevulinic acid (ALA) on nerve-muscle function have been examined using the frog sciatic gastrocnemius preparation. Levels of ALA that did not interfere with nerve conduction did inhibit the muscle's response to nerve stimulation for a period of 50 – 120 min. The amounts of ALA within muscle were declining at 2 hr after topical administration. It is suggested that some of the symptoms in acute attacks of intermittent porphyria may be attributable to effects from ALA. |
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