3H-clozapine binding to rat brain membranes |
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Authors: | Danie Hauser Annemarie Closse |
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Affiliation: | SANDOZ Ltd, Pharmaceutical Division, Chemical Research CH-4002 Basle, Switzerland |
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Abstract: | 3H-Clozapine binds specifically and with high affinity (KD = 1.3 nM) to rat brain membranes. About two thirds of reversibly bound 3H-clozapine are displaced by hyoscyamine in a stereospecific manner, suggesting interaction of clozapine with muscarinic cholinergic receptors. Most of the remaining 3H-clozapine binding is stereospecifically inhibited by butaclamol, but this binding component seems not to be related to dopamine receptors. |
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