Role of prostaglandis in the control of renin secretion in the dog (II) |
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| Authors: | John C.H. Yun Gerald D. Kelly Frederic C. Bartter George W. Smith |
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| Affiliation: | 1. The Department of Physiology and Biophysics, Howard University, Washington, D.C., USA;2. Hypertension-Endocrine Branch, National Heart, Lung, USA;3. Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, USA |
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| Abstract: | Infusion of prostaglandin E1 (PGE1) into the renal artery of anesthetized dogs (1.03 μg/min) caused increases in urine flow rate (V), renal plasma flow (RPF) and renin secretion rate without any change in mean arterial blood pressure (MABP), whereas infusion of prostaglandin F2α (PGF2α), (1.03 μg/min) caused no consistent change in V, RPF, or renin secretion rate. Infusion of prostaglandin E2 (PGE2) (1.03 μg/min) into the renal artery of “non-filtering” kidneys caused renin secretion rate to rise from 567.7 ± 152.0 U/min(M ± SEM) during control periods to 1373.6 ± 358.5 U/min after 60 minutes of infusion of PGE2 (P < 0.01), without significant change in MABP (P > 0.1). The data suggest that PGE1 and PGE2 play a role in the control of renin secretion. The data further suggest that PGE may control renin secretion through a direct effect on renin-secreting granular cells. |
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