Effects of cholinergic drugs on growth hormone release |
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Authors: | JF Bruni J Meites |
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Institution: | Department of Physiology, Neuroendocrine Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA |
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Abstract: | Acetylcholine and the cholinergic agonists, pilocarpine and physostigmine, increased GH release . The increase in GH release by pilocarpine was reversed by concurrent administration of the cholinergic receptor blocker, atropine, whereas atropine alone did not alter serum GH concentrations. Cholinergic stimulation of GH release appears to be partially mediated through a catecholaminergic system since the response was partially inhibited by pimozide, a dopamine receptor blocker, or phentolamine, an α-adrenergic receptor blocker. The cholinergic system may function physiologically to help regulate GH release. |
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