Comparative effects of 1, 10-phenanthroline and 1, 7-phenanthroline on DNA and RNA synthesis in mouse spleen |
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Authors: | Chi-Hsiung Chang John W. Yarbro |
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Affiliation: | Department of Pharmacology, School of Pharmacy, Temple University Philadelphia, Pennsylvania, 19140, USA |
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Abstract: | When 1, 10-phenanthroline at 10?4 mole/kg was administered intraperitoneally to C3H mice, a significant decrease of (32P) Na2HPO4 incorporation into splenic DNA and RNA was noted within 15 min. The same dose or higher was required to significantly inhibit the incorporation of (5-3H) uridine and (methyl-3H) thymidine into splenic nucleic acid. 1, 10-phenanthroline also decrease the incorporation of the 32P into DNA and RNA in 6C3HED ascites tumor. 1, 7-phenanthroline, a non-chelating analogue at 10?4 mole/kg, less effectively altered the rate of the 32P incorporation into splenic nucleic acid within 15 min, but significantly inhibited the incorporation within 1 hr. |
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