Effect of L-DOPA pretreatment on invivo protein synthesis in various rat brain regions |
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| Authors: | L.E. Roel P. Levine D. Rubin D. Markovitz H.N. Munro R.J. Wurtman |
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| Affiliation: | Laboratory of Neuroendocrine Regulation and Laboratory of Physiological Chemistry Department of Nutrition and Food Science Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA |
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| Abstract: | A single dose of L-dihydroxyphenylalanine (L-DOPA, 500 mg/kg, i.p.) that caused massive disaggregation of brain polysomes also suppressed the incorporation of [3H] lysine into trichloracetic acid (TCA)-precipitable proteins of cortex, cerebellum, hypothalamus, brainstem and striatum. The magnitude of this inhibition of [3H] protein synthesis was similar in all brain regions studied, and was not related to changes in the specific activity of the precursor amino acid. |
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| Keywords: | To whom reprint requests should be sent. |
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