Ligand binding to dopamine-receptors: Analysis & interpretation |
| |
Authors: | A.J. Beld B. Kuijer J.F. Rodrigues de Miranda A.C. Wouterse |
| |
Affiliation: | Pharmacological Institute, University of Nijmegen, Nijmegen, The Netherlands |
| |
Abstract: | Dopamine receptor interaction was studied by concentration dependent inhibition of 3H-Spiperone binding to calf caudate nucleus homogenates with (+)-butaclamol, haloperidol, ergometrine, apomorphine and dopamine. The results were analyzed in terms of a one and a two site receptor model using computerized curve fitting procedures. Evidence is given in favour of a two site receptor model on basis of statistical criteria. The presence of two independent non-interconverting receptor sites for dopamine in calf caudate nucleus is consistent with binding data from others and with in vivo experiments. |
| |
Keywords: | To whom correspondence should be addressed. |
本文献已被 ScienceDirect 等数据库收录! |