Investigations concerning the cellular origin of dopamine receptors |
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| Authors: | FA Henn M Titeler DJ Anderson K May |
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| Institution: | 1. Neurochemistry Research Laboratories, Department of Psychiatry University of Iowa, 500 Newton Road, Iowa City, Iowa 52242, USA;2. Departments of Anatomy, University of Iowa and Howard Univ., Washington, D.C., USA |
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| Abstract: | The cellular investigation of dopamine receptors was examined using glial cell fractions and synaptic fractions prepared from bovine caudate. Binding of the dopamine agonist apomorphine and antagonist spiroperidol was examined. A fractionation of bovine substantia nigra was developed. No evidence of haloperidol binding was found in neuronal, glial or synaptosomal fractions from this tissue. Finally, an autoradiographic localication of 3H]-haloperidol was undertaken. The results support the astroglial localization of a significant portion of the dopamine receptors. |
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