Enzymatic sulfation of bile salts: III. Enzymatic sulfation of taurolithocholate in human and guinea pig fetuses and adults |
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| Authors: | Lee-Jing Chen MM Thaler RJ Bolt MS Golbus |
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| Institution: | 1. From the Department of Internal Medicine, University of California, Davis, USA;2. Department of Pediatrics and Obstetrics and Liver Center, University of California, San Francisco, California, USA |
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| Abstract: | The activities of bile salt sulfotransferase, the enzyme responsible for the sulfation of bile salts, were determined in fetal and adult livers of humans and guinea pigs. Fetal enzyme activities in guinea pigs were approximately one-tenth of the adult and increased gradually as the gestation progressed. The bile salt sulfotransferase activities were found in human fetal livers but only 14% of the adult fatty liver activity. The result indicates human or guinea pig fetuses are capable of sulfating lithocholate derived from the mother. |
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