The effect of amphetamines on culture myotubes: Selective inhibition of protein synthesis |
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Authors: | Raphael Salomon |
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Affiliation: | Department of Neurobiology, The Weizmann Institute of Science Rehovot, Israel. |
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Abstract: | d-amphetamine sulfate, p-chloramphetamine and fenfluramine (10–100μM concentrations) were found to selectively inhibit protein synthesis in cultured chick myotubes. The most strongly inhibited cellular protein was a 34000 dalton polypeptide; myosin was affected to a smaller extent, while actin and tubulin were the least affected. 25μM of the drugs, or more, inhibited the incorporation of amino acid into proteins by 50%, while not reducing the acetylcholinesterase activity. The selective inhibition of protein synthesis may be one possible mechanism of the long-lasting effects of those drugs. |
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