Identification of 4-acetoxyaminoquinoline from the hydrolysis of 1-acetoxy-4-acetoxyimino-1,4-dihydroquinoline,in vitro and in vivo properties |
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Authors: | B Bailleul S Galiègue M Demeunynck MF Lhomme J Lhomme MH Loucheux-Lefebvre |
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Institution: | 1. Institut de Recherches sur le Cancer de Lille et Unité INSERM no. 124, BP 311, F-59020 Lille Cédex France;2. Laboratoire de Chimie Organique Biologique, ERA CNRS no. 827, Université de Lille I, F-59655 Villeneuve d''Ascq France |
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Abstract: | 4-Acetoxyaminoquinoline (Ac-4-HAQ) (1) was identified as a hydrolysis product of 1-acetoxy-4-acetoxyimino-1,4-dihydroquinoline (diAc-4-HAQO). The reaction allowing the obtention of (1) obeys to a reduction mechanism implying the N1-O cleavage. The carcinogenic properties of (1) observed by Sato et al. (Japan J. Exp. Med., 40 (1970) 475) in mice were studied in rats with the in vivo system we used previously with 4-nitroquinoline-1-oxide (4-NQO) and 4-hydroxyaminoquinoline-1-oxide (4-HAQO). In rats (1) does not covalently bind DNA. It was, therefore, possible to propose an interpretation of the results obtained by Enomoto et al. (Proc. Soc. Exp. Biol. Med., 136 (1971) 1206) who injected diAc-4-HAQO s.c. to mice and rats. Compound 1 could be responsible for the carcinogenic effects observed through the following pathway: (1) should be formed by hydrolysis of diAc-4-HAQO and reactivated by an enzymatic system to N-oxide derivative, the 4-acetoxyaminoquinoline-1-oxide (Ac-4-HAQO), which constitutes an ultimate carcinogen model of 4-NQO. |
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Keywords: | 4-Nitroquinoline-1-oxide 4-Nitroquinoline 4-Acetoxyaminoquinoline 1-Acetoxy-4-acetoxyimino-1 4-dihydroquinoline Carcinogenesis Ac-4-HAQ 4-acetoxyaminoquinoline Ac-4-HAQO 4-hydroxyaminoquinoline-1-oxide diAc-4-HAQO 1-acetoxy-4-acetoxyimino-1 4-dihydroquinoline 4-ClQ 4-chloroquinoline 4-HAQO 4-hydroxyaminoquinoline-1-oxide HPLC high pressure liquid chromatography 4-NQ 4-nitroquinoline 4-NQO 4-nitroquinoline-1-oxide NMR nuclear magnetic resonance |
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