Calcium Channels in the Nuclear Envelope of Pyramidal Neurons of the Rat Hippocampus |
| |
Authors: | E A Fedorenko D E Duzhii S M Marchenko |
| |
Institution: | (1) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine |
| |
Abstract: | As is known, an increase in the concentration of Са2+ in the nuclei of nerve cells leads to activation of genes responsible for the formation of long-lasting postsynaptic changes;
mechanisms of memory and learning are based on such changes. The pathways necessary for the entry of calcium into the nuclei
of hippocampal pyramidal neurons remained unstudied. Using a patch-clamp technique, we studied what types of calcium channels
exist in the membranes of isolated nuclei of pyramidal neurons of the hippocampal СА1 area. In the inner nuclear membrane of these cells, we, for the first time, found inositol trisphosphate receptors (IP3Rs) activated by inositol trisphosphate applied in the concentration of ≥0.1 μM. The conductivity of single channels of such
receptors was, on average, 366 pS; these channels were permeable for both monovalent and bivalent cations. Our data indicate
that the nuclear envelope of pyramidal neurons of the hippocampal СА1 area can play the role of the calcium store from which Са2+ enter the cell nucleus directly.
Neirofiziologiya/Neurophysiology, Vol. 40, No. 4, pp. 288–292, July–August, 2008. |
| |
Keywords: | pyramidal neurons of the hippocampus nuclear envelope inositol trisphosphate receptors calcium channels calcium store |
本文献已被 SpringerLink 等数据库收录! |
|