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Positional clustering of differentially expressed genes on human chromosomes 20, 21 and 22
Authors:Karine?Mégy,Stéphane?Audic,Jean-Michel?Claverie  author-information"  >  author-information__contact u-icon-before"  >  mailto:Jean-Michel.Claverie@igs.cnrs-mrs.fr"   title="  Jean-Michel.Claverie@igs.cnrs-mrs.fr"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:(1) Genomic and Structural Information, UMR 1998 CNRS / Aventis, 31, chemin Joseph Aiguier, 13402 Marseille Cedex 20, France;
Abstract:

Background  

Clusters of genes co-expressed are known in prokaryotes (operons) and were recently described in several eukaryote organisms, including Human. According to some studies, these clusters consist of housekeeping genes, whereas other studies suggest that these clustered genes exhibit similar tissue specificity. Here we further explore the relationship between co-expression and chromosomal co-localization in the human genome by analyzing the expression status of the genes along the best-annotated chromosomes 20, 21 and 22.
Keywords:
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