Microsatellite variation, repeat array length, and population history of Plasmodium vivax |
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| Authors: | Imwong M Sudimack D Pukrittayakamee S Osorio L Carlton J M Day N P J White N J Anderson T J C |
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| Institution: | * Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;  Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas;  Malaria Research Group, International Centre for Medical Research and Training, Cali, Colombia;  The Institute for Genomic Research, Rockville, Maryland; and || Centre for Tropical Medicine and Vaccinology, Churchill Hospital, Oxford, United Kingdom |
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| Abstract: | A recent paper (Leclerc et al. 2004 ) described limited variationin dinucleotide microsatellites from Plasmodium vivax, suggestingvery recent bottlenecks or genome-wide selective events. Wedescribe patterns of variation in 11 dinucleotide microsatellitesin P. vivax populations from Colombia, India, and Thailand.We find abundant variation with heterozygosity of 0.64, 0.76,and 0.77, respectively, in the three countries. The discrepancybetween these two studies results is simply explained by thedifferences in the size of repeat arrays. The microsatellitesstudied by Leclerc et al. (2004) have very few repeats (median5.5, range 4–13) and so would not be expected to be variable.Plasmodium vivax microsatellites show comparable levels of variationto those in Plasmodium falciparum when repeat array length istaken into account and provide no support for recent bottlenecksor widespread selective purging |
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| Keywords: | microsatellite array length heterozygosity selection bottleneck |
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