Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension |
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| Authors: | Karen A Fagan Brian Morrissey Brian W Fouty Koichi Sato Julie Wright Harral Kenneth G Morris Jr Marloes Hoedt-Miller Shanda Vidmar Ivan F McMurtry David M Rodman |
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| Institution: | (1) Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA;(2) Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, Colorado, USA |
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| Abstract: | Background The importance of nitric oxide (NO) in hypoxic pulmonary hypertension has been demonstrated using nitric oxide synthase (NOS) knockout mice. In that model NO from endothelial NOS (eNOS) plays a central role in modulating pulmonary vascular tone and attenuating hypoxic pulmonary hypertension. However, the normal regulation of NOS expression in mice following hypoxia is uncertain. Because genetically engineered mice are often utilized in studies of NO, we conducted the present study to determine how hypoxia alters NOS expression in wild-type mice. |
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