T-type calcium channels: the never ending story |
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Authors: | Nilius Bernd Talavera Karel Verkhratsky Alexei |
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Institution: | Laboratorium voor Fysiologie, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. bernd.nilius@med.kuleuven.be |
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Abstract: | T-type, or low-voltage-activated (LVA), tiny and transient Ca2+ currents pare more and more recognised as universal players in a plethora of cell functions and are also more and more connected to several diseases. This short introduction reviews the discovery of T-type Ca2+ channels, describes its basic properties and sketches its cloning and physiological impact. Finally, an overview is given how research on T-type Ca2+ channels has developed in the last years and in which topics it is branching out, a process, which is still ongoing. |
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