Pyramidal cell-to-inhibitory cell spike transduction explicable by active dendritic conductances in inhibitory cell |
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Authors: | Roger D. Traub Richard Miles |
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Affiliation: | (1) IBM Research Division, T.J. Watson Research Center, 10598 Yorktown Heights, NY, USA;(2) Department of Neurology, Columbia University, 10032 New York, NY, USA;(3) Institut Pasteur, 28 Rue du Dr. Roux, 75724 Paris Cedex 15, France |
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Abstract: | In the guinea-pig hippocampal CA3 region, the synaptic connection from pyramidal neurons tostratum pyramidale inhibitory neurons is remarkable. Anatomically, the connection usually consists of a single release site on an interneuronal dendrite, sometimes 200 m or more from the soma. Nevertheless, the connection is physiologically powerful, in that a single presynaptic action potential can evoke, with probability 0.1 to 0.6, a postsynaptic action potential with latency 2 to 6 ms. We construct a model interneuron and show that the anatomical and physiological observations can be reconciled if the interneuron dendrites are electrically excitable. Excitable dendrites could also account for depolarization-induced amplification of the pyramidal cell-interneuron EPSP in the voltage range subthreshold for spike generation. |
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Keywords: | recurrent excitation synaptic integration dendritic electrogenesis |
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