Role of cyclic AMP on differentiation of T- and B-lymphocytes during the immune induction. |
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Authors: | Rita Bösing-Schneider Margarete Haug |
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Affiliation: | Immunology Unit, Department of Biology, University of Konstanz, 7750 Konstanz, Germany |
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Abstract: | Spleen cell cultures from genetically thymus-deficient nude mice were restored with a T-cell replacing factor obtained from normal spleen cells of Balb/c-Igb mice stimulated with concanavalin A. Treatment of these cultures with an inhibitory dose of cyclic AMP did not result in reduction of the number of specific antibody-forming cells after stimulation by antigen, whereas the same treatment led to inhibition in cultures restored with normal hydrocortisone-resistant thymus lymphocytes. Further experiments lead to the conclusion that the early effect of cAMP on the immune induction seen in vitro reflects inhibition of the production or secretion of a T-cell factor which is a prerequisite for triggering B-cells with a thymus-dependent antigen. |
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