Two types of linkage between codon usage and gene-expression levels |
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Authors: | T Nakamura A Suyama A Wada |
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Institution: | Department of Physics, Faculty of Science, University of Tokyo, Japan. |
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Abstract: | The relation between codon usage and gene-expression levels is an intensively investigated and discussed topic in the field of molecular evolution. We statistically analyzed 25 Escherichia coli gene sequences by a new classification of synonymous codons and found that (i) there are two distinct types of linkage between codon usage and gene-expression levels in E. coli, and (ii) one of the two kinds of codon preferences (the codon preference concerned with interaction of GC/AT choice at three codon positions) is observed significantly in weakly expressed genes. |
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