The formation of heteroagglutinins in rats "chemically" splenectomized by ethyl palmitate, in comparison to animals surgically splenectomized. |
| |
Authors: | V Sebestik A Majsky I Potm?silova J Jelínek |
| |
Abstract: | In Wistar rats "chemically splenectomized" by an i.v. injection of ethyl palmitate the formation of heteroagglutinins against human O-erythrocytes has been followed. Ethyl palmitate applied 2 hrs before immunization induced on the 5th day a significant decrease of the antibody level. This temporary inhibition, however, was at a later stage replaced by a significant increase of antibody level with the peak of 8--14 days. Animals surgically splenectomized 24 hrs prior to immunization displayed a weak antibody response throughout the experiment. An injection of the ethyl palmitate on the 6th day after immunization induced a pronounced and persistent decrease of the antibody level. Surgical splenectomy performed within the same interval had a comparable effect. The experiments revealed that the inhibitory effect of ethyl palmitate on antibody production was temporary only, and at a later stage could be compensated by an enhanced antibody activity. |
| |
Keywords: | |
|
|