PKM2 and the tricky balance of growth and energy in cancer |
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| Authors: | Macintyre Andrew N Rathmell Jeffrey C |
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| Affiliation: | Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. |
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| Abstract: | In this issue of Molecular Cell, Lv et al. (2011) identify a novel feedback mechanism in which increased glycolysis induces the acetylation and chaperone-mediated autophagic degradation of the glycolytic regulator PKM2, revealing a novel metabolic feedback loop that drives tumor growth. |
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