AUF1在病毒感染及相关炎症反应中的调控作用

富含AU元件的RNA结合蛋白1(AU-rich element binding factor 1,AUF1)具有剪接加工前体mRNA、转运和降解成熟mRNA的功能,同时调节带有富含AU元件(AU-rich element,ARE)的mRNA翻新。AUF1通过介导炎性细胞因子及其反应从而控制炎症进程。研究表明,AUF1与肠道病毒71型的内部核糖体进入位点(internal ribosome entry site,IRES)结合并与其交互负性调节病毒翻译与复制,它还可被募集到柯萨奇病毒B3型和肠道病毒71型诱导的应激颗粒中。

Role of AUF1 in viral infection and related inflammation

Regulated messenger RNA (mRNA) decay is an essential mechanism that governs proper control of gene expression .AU-rich element RNA-binding factor 1 (AUF1 ) exhibits the characteristics of a trans-acting factor contributing to the rapid turnover of many cellular mRNAs .AUF1 controls the process of inflammation by mediating inflammatory cytokines and their responses .Studies show that AUF1 binds the internal ribosome entry site (IRES) of enterovirus 71 (EV71) and interacts with IRES to negatively regulate viral translation and replication .AUF1 could be recruited to the stress granules induced by coxsackievirus B3 and enterovirus 71 .